Follows Jimmy Neutron, his faithful robotic dog, Goddard, and his eclectic friends and family as they experience life in Retroville. Jimmy is a typical kid, who just happens to be a genius. He creates gadgets to improve his everyday life, but his inventions go awry more often then not, and hilarious trouble ensues.

Aliens abduct all adults; genius Jimmy and his friends build an interstellar spacefleet and rescue them, and get home in time for dinner.